| Popis: |
The use of mass spectrometry for quantitative analysis began with the very first published experiment in 1913. Therefore, current applications, including quantitative proteomics, are based on an extensive foundation of fundamental and applied investigations. This history also applies to selected reaction monitoring. The ability of tandem mass spectrometry to enhance the specificity of an analysis was apparent in the 1970s and the technique has a strong history of use for many classes of small molecules. As a result, the application of selected reaction monitoring to targeted quantitative proteomics can be seen as a straight-forward experiment based on sound principles, excellent equipment, and a distinguished history. |
