Extractive crystallization of cabotegravir in droplet-based microfluidic devices
| Autor: | Robin Fortt, Robert M. Tona, Pablo M. Martin-Soladana, Nathalie Douillet, Gareth Ward, David Lai, Jack Durrant |
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| Rok vydání: | 2020 |
| Předmět: |
010302 applied physics
Active ingredient Materials science Microfluidics Dispersity 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences law.invention Inorganic Chemistry Solvent chemistry.chemical_compound Cabotegravir Chemical engineering chemistry Agglomerate law 0103 physical sciences Materials Chemistry Solvent composition Crystallization 0210 nano-technology |
| Zdroj: | Journal of Crystal Growth. 552:125908 |
| ISSN: | 0022-0248 |
| Popis: | Monodisperse emulsions of solvent saturated with the active pharmaceutical ingredient (API) cabotegravir were generated by microfluidic devices. In contrast to model oil-water emulsions that provide idealized conditions for obtaining highly monodisperse emulsions, APIs impart strict limitations on solvent choice. To provide a suitable environment in which extractive crystallization could occur, and to enhance reproducibility, co-solvents were introduced. Subsequently, the effect of each solvent component on morphology and size was observed. Through the manipulation of solvent composition, particles of both plate-like and spherical multi-crystal agglomerates were obtained, providing the ability to tune the operating conditions to provide particles with desirable characteristics such as size, shape and flowability. Scale-up of the manufacturing process was addressed through the application of existing microfluidic parallelization techniques, resulting in a 100-fold increase in throughput over a single-channel device. Subsequently, the obtained pure, and excipient-bound, API spherical agglomerates, were subjected to batch isolation and washing. |
| Databáze: | OpenAIRE |
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