Development of a photocurable gelatin-based gelation material for application to periodontal regeneration
| Autor: | Yasuhide Nakayama, Yasuo Hosaka, Chie Fukaya, Taneaki Nakagawa, Sadao Omata, Yoshinobu Murayama, Ayaka Ishikawa |
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| Rok vydání: | 2008 |
| Předmět: |
chemistry.chemical_classification
Aqueous solution food.ingredient Eosin General Chemical Engineering General Physics and Astronomy General Chemistry Polymer Gelatin Physical property chemistry.chemical_compound food chemistry Chemical engineering Polymer chemistry Self-healing hydrogels Curing (chemistry) Visible spectrum |
| Zdroj: | Journal of Photochemistry and Photobiology A: Chemistry. 199:255-260 |
| ISSN: | 1010-6030 |
| DOI: | 10.1016/j.jphotochem.2008.05.027 |
| Popis: | Novel photocurable materials, comprised mixed aqueous solutions of photoreactive gelatin – gelatin partially derivatized with eosin – and polyamine, which is a polymer of N , N -dimethylaminopropylacrylamide, were designed. The materials had appropriate viscosity for shape formation at 37 °C. When photoirradiated with a clinically used visible light source, the materials were almost completely converted to hydrogels to fix their shape in the desired form within several tenths of a second. Cells that were seeded on the eosin–gelatin-coated surface showed good proliferation. Negligible cytotoxicity of eosin–gelatin was confirmed when culturing was performed in the presence of a large amount of eosin–gelatin. The developed photocurable materials could be converted to a hydrogel with desired physical property change by using a convenient curing procedure of photoirradiation at any desired time and in any shape with minimal cytotoxicity, which was appropriate for the application in periodontal tissue regeneration. |
| Databáze: | OpenAIRE |
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