Abstract 2657: The Increased Local Insulin-like Growth Factor-1 To IGF Binding Protein-3 Ratio In The Pathogenesis Of The Left Ventricular Hypertrophy In Humans: Augmentation By Matrix Metalloproteinase-2 Activity

Autor:	Naoki Abe, Toshiro Matsunaga, Kunihiko Kameda, Hirofumi Tomita, Tomohiro Osanai, Kozo Fukui, Ikuo Fukuda, Ken Okumura
Rok vydání:	2007
Předmět:	Physiology (medical) cardiovascular system Cardiology and Cardiovascular Medicine
Zdroj:	Circulation. 116
ISSN:	1524-4539 0009-7322
DOI:	10.1161/circ.116.suppl_16.ii_589
Popis:	Insulin-like growth factor (IGF)-1 is a potent mitogen and is said to enhance ventricular hypertrophy. IGF-1 is present as an IGF-1-IGF binding protein-3 (IGFBP-3) complex, and its free form shows bioactivity. Recently, the matrix metalloproteinases (MMPs) were shown to facilitate IGF-1 bioactibity through the degradation of IGFBP-3. To clarify the relation of IGF-1 and IGFBP-3 to MMPs and their roles in human cardiac hypertrophy, we measured levels of total IGF-1, IGFBP-3, MMP-2, and MMP-9 in the pericardial fluid, which reflects the myocardial interstitial fluid, obtained from 51 patients with aortic valvular disease (AVD) (n=36) (aortic stenosis (n=24), aortic regurgitation (n=12)) and mitral valvular disease (MVD) (n=15) (mitral stenosis (n=6), mitral regurgitation (n=9)) who underwent open heart surgery. Levels of total IGF-1 and IGFBP-3 were measured by enzyme immunoassay, and the activities of MMP-2 and MMP-9 by gelatin zymography. Left ventricular mass index (LVMI) was estimated by echocardiography. Pericardial total IGF-1 level (ng/ml) in AVD (32±19) was higher than that in MVD (20±17) (p
Databáze:	OpenAIRE
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