Palladium-Catalyzed Synthesis of Diaryl Ketones from Aldehydes and (Hetero)Aryl Halides via C–H Bond Activation
| Autor: | Takayuki Wakaki, Motomu Kanai, Takaya Togo, Daisuke Yoshidome, Yoichiro Kuninobu |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
C h bond Ketone 010405 organic chemistry Aryl chemistry.chemical_element Halide General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Aldehyde Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Density functional theory Palladium |
| Zdroj: | ACS Catalysis. 8:3123-3128 |
| ISSN: | 2155-5435 |
| DOI: | 10.1021/acscatal.8b00440 |
| Popis: | We developed a palladium-catalyzed C–H transformation that enabled the synthesis of ketones from aldehydes and (hetero)aryl halides. The use of picolinamide ligands was key to achieving the transformation. Heteroaryl ketones, as well as diaryl ketones, were synthesized in good to excellent yields, even in gram-scale, using this reaction. Results of density functional theory (DFT) calculations support the C–H bond activation pathway. |
| Databáze: | OpenAIRE |
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