Effect of transgenic overexpression of BMP antagonist noggin on chemically-induced skin carcinogenesis

Autor:	M. G. Terentyeva, G. A. Larionov, V. S. Gordova, N. V. Mardaryeva, Andrei N. Mardaryev
Rok vydání:	2020
Předmět:	animal structures integumentary system Transgene embryonic structures Cancer research medicine Bmp antagonist Noggin Biology Carcinogenesis medicine.disease_cause
Zdroj:	IOP Conference Series: Earth and Environmental Science. 433:012047
ISSN:	1755-1315 1755-1307
DOI:	10.1088/1755-1315/433/1/012047
Popis:	To study the role of BMP signaling pathway in the development of skin tumors, we employed two-stage chemical carcinogenesis protocol on K14-Noggin mice expressing BMP antagonist noggin in the epidermis. A comparative analysis showed an earlier appearance and a significant increase in the number of skin papillomas in K14-Noggin mice compared to the wild-type control (FVB). In contrast to control mice, the transgenic K14-Noggin mice also developed squamous cell carcinoma with local metastasis of malignant cells into the dermis of the skin. The results of this work indicate the tumor suppressive role of BMP signaling pathway in the skin epithelium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::93e218ce8fde01470c9738dfc96b57ec https://doi.org/10.1088/1755-1315/433/1/012047 Zobrazit plný text záznamu