Effects of the antimicrotubular cancerostatic drug nocodazole on the yeast Saccharomyces cerevisiae

Autor:	W. Künkel
Rok vydání:	2007
Předmět:	Budding Cell division Cell Saccharomyces cerevisiae General Medicine Biology biology.organism_classification Applied Microbiology and Biotechnology Spindle pole body Yeast Cell biology Nocodazole chemistry.chemical_compound medicine.anatomical_structure chemistry Microtubule Genetics medicine
Zdroj:	Zeitschrift für allgemeine Mikrobiologie. 20:315-324
ISSN:	1521-4028 0044-2208
DOI:	10.1002/jobm.19800200503
Popis:	Nocodazole completely inhibited cell division of Saccharomyces cerevisiae, contrary to methylbenzimidazole-2-ylcarbamate, estimated by cell counting. Growth as measured by turbidity and dry weight estimations, however, was not influenced. Treatment for two hours with nocodazole interrupts the budding cycle of the yeast within a period when bud and mother cells have reached equal sizes. Dependent on duration of nocodazole treatment stretched or dumb-bell shaped nuclei are localized between bud and mother cell or two daughter nuclei are present. It has been shown by electron microscopy that nocodazole neither destroyed karyo- nor ground-plasmic microtubules. The spindle pole bodies (spb), however, reached double the normal size approximately.
Databáze:	OpenAIRE
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