| Autor: |
Ravi K. Birla, Kavya L. Singampalli, Asela Nieuwsma, Sunita Brimmer, Aditya Kaul, Lalita Wadhwa, Sung Y. Jung, Dereck Mezquita, Sandra Grimm, Swathi Balaji, Cristian Coarfa, Christopher Caldarone, Jane Grande-Allen, Sundeep G. Keswani |
| Rok vydání: |
2023 |
| DOI: |
10.1101/2023.01.22.525022 |
| Popis: |
Discrete subaortic stenosis (DSS) is a pediatric condition in which a fibrotic membrane forms within the left ventricular outflow track. The fibrotic membrane is removed surgically; however, there is a high rate of reoccurrence which requires a second surgery. There are currently no tools available to predict the risk of reoccurrence in DSS patients, a limitation addressed by this study. In this study, we analyzed resected fibrotic membranes for DSS patients at the time of first surgery for non-recurrent and recurrent patients, and at the time of second surgery for recurrent patients. RNA-sequencing was conducted to obtain a global screen of changes in RNA expression while mass spectrometry was used to obtain a global screen of changes in protein expression. The results from the RNA-sequencing and mass spectrometry provide valuable insight into genes and the proteins that are differentially regulated in recurrent vs non-recurrent DSS patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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