| Autor: |
Hidetaka Okada, Atsushi Kasamatsu, Tomoko Tsuzuki, Tomoo Yoshimura, Hiromi Murata, Hideharu Kanzaki |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Uterine Endometrial Function ISBN: 9784431559702 |
| DOI: |
10.1007/978-4-431-55972-6_6 |
| Popis: |
The physiological changes in the endometrium in response to hypoxia and female sex hormones are associated with profound angiogenesis. Hypoxia in the endometrial tissues is a major regulator of endometrial angiogenesis and remodeling during menstruation. Estradiol plays an important role in the reconstruction of a new vascular network and rapid vessel growth in the endometrium. Progesterone is a key factor in vascular maturation and decidualization. Further, endometrial angiogenesis is tightly controlled by a variety of angiogenic and antiangiogenic factors including vascular endothelial growth factor (VEGF), soluble VEGF receptor-1, angiopoietin, and CXCL12. Hypoxia and female sex hormones are involved in the regulation of the angiogenic factors in an independent manner in human endometrium. Analysis of the process of angiogenesis in the human endometrium will enhance our understanding of normal endometrial vascular remodeling. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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