Follicular dendritic cells share a membrane-bound protein with fibroblasts

Autor: Margarita Bofill, Arne N. Akbar, Peter Amlot
Rok vydání: 2000
Předmět:
Zdroj: The Journal of Pathology. 191:217-226
ISSN: 1096-9896
0022-3417
DOI: 10.1002/(sici)1096-9896(200006)191:2<217::aid-path586>3.0.co;2-6
Popis: The expression of a fibroblast antigen (AS02) on a proportion of CD21+ follicular dendritic cells (FDCs) provides evidence in support of their fibroblastic reticular origin. This antigen is expressed on the membrane of tissue fibroblasts but is absent from lymphocytes, macrophages or granulocytes. The distribution of AS02 in conjunction with other FDC markers (DRC-1, RFD3, CD23, IgM, and vitronectin) showed six types of FDCs. AS02 is present in the outer layers of primary and secondary follicles, but gradually decreases and disappears in the centre of germinal centres. In contrast, there is a progressive up-regulation of the other FDC markers. AS02 is re-expressed in involuting FDCs. Intermediate forms from fibroblastic to dendritic appearance are also apparent and occasionally FDC processes contain collagen type I and IV fibres, a characteristic feature of fibroblasts. In pathological follicles the normal differentiation pattern is disrupted, with persistence of the fibroblast marker, possibly due to altered interactions between FDCs and disrupted lymphocytic patterns. These findings provide new evidence for a local differentiation pathway of fibroblasts to mature FDCs.
Databáze: OpenAIRE
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