Microwave-assisted Claisen rearrangement of naphthyl 2-propynyl ethers: synthesis of naphthofurans

Autor:	Abraham Thomas, Dnyaneshwar Harishchandra Dahale, Kagga Mukkanti, Balasubramanian Gopalan, V. S. Prasada Rao Lingam
Rok vydání:	2012
Předmět:	Reaction conditions Propynyl Organic Chemistry Biochemistry Microwave assisted Claisen rearrangement chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Propargyl Microwave irradiation Organic chemistry Mitsunobu reaction
Zdroj:	Tetrahedron Letters. 53:5695-5698
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.08.053
Popis:	An efficient two-step approach for the synthesis of naphtho[1,2- b ]furans and naphtho[2,1- b ]furans has been developed. Various functionalized propargyl alcohols were etherified with α- or β-naphthol under Mitsunobu reaction conditions to give naphthyl 2-propynyl ethers, which underwent a facile microwave-assisted Claisen rearrangement and concomitant anionic cyclization to yield naphthofuran derivatives under basic reaction conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::93c4ebb855330b16c5c6637a170fd1f8 https://doi.org/10.1016/j.tetlet.2012.08.053 Zobrazit plný text záznamu Full Text from ScienceDirect