A canine model of chronic ischemic heart failure
Autor: | Muhammad S. Khan, Douglas Smego, Yuki Ishidoya, Annie M. Hirahara, Emmanuel Offei, Martha S. Ruiz Castillo, Omar Gharbia, Hui Li, Joseph A. Palatinus, Lauren Krueger, TingTing Hong, Guillaume L. Hoareau, Ravi Ranjan, Craig H. Selzman, Robin M. Shaw, Derek J. Dosdall |
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Rok vydání: | 2023 |
Předmět: | |
Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 324:H751-H761 |
ISSN: | 1522-1539 0363-6135 |
Popis: | The novel total left anterior descending devascularization (TLD) approach in a canine ischemic heart failure model limits collateral flow in the ischemic zone and provides excellent early survival and repeatable development of chronic ischemic heart failure in the canine heart. This work provides a consistent large animal model for investigating heart failure mechanisms and testing novel therapeutics. |
Databáze: | OpenAIRE |
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