Analysis of the Structure of Polyhydroxybutyrate-Based Fibrous Matrices for Prolonged Drug Release
| Autor: | A. L. Iordanskii, E. L. Kucherenko, V. S. Markin, A. A. Ol’khov, R. Yu. Kosenko, V. I. Perov |
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| Rok vydání: | 2019 |
| Předmět: |
010302 applied physics
chemistry.chemical_classification Materials science Scanning electron microscope General Engineering Supramolecular chemistry 02 engineering and technology Polymer 021001 nanoscience & nanotechnology 01 natural sciences Electrospinning Amorphous solid law.invention Polyhydroxybutyrate Differential scanning calorimetry chemistry Chemical engineering law 0103 physical sciences General Materials Science Crystallization 0210 nano-technology |
| Zdroj: | Inorganic Materials: Applied Research. 10:806-811 |
| ISSN: | 2075-115X 2075-1133 |
| Popis: | —This paper studies the supramolecular structure of polymer matrices for prolonged release of medicinal substances on the basis of ultrafine polyhydroxybutyrate fibers obtained by electrospinning. Dipyridamole was chosen as a model drug. The concentration of dipyridamole in the fibers ranged from 1 to 5%. Using the methods of scanning electron microscopy, differential scanning calorimetry, and electron paramagnetic resonance, the morphology of nonwoven fibrous materials was investigated. It was found that the geometry of the fibers changes upon adding dipyridamole. Polyhydroxybutyrate fibers are characterized by a nonequilibrium supramolecular structure. Introduction of dipyridamole leads to additional crystallization of the fibers, which is also accompanied by slowing down of molecular mobility in the amorphous regions of the polymer. |
| Databáze: | OpenAIRE |
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