A bioinspired approach for construction of the [7-5-6-5] all-carbon tetracyclic core of logeracemin A

Autor:	Bin Cheng, Lingzhi Gao, Liang Xu, Jiang-Li Wang, Su-Yan Cao, Hui-Jie Yue
Rok vydání:	2019
Předmět:	010405 organic chemistry Chemistry Stereochemistry Organic Chemistry chemistry.chemical_element Sequence (biology) 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Dehydration reaction Aldol reaction Carboxylate Carbon
Zdroj:	Organic Chemistry Frontiers. 6:813-816
ISSN:	2052-4129
DOI:	10.1039/c9qo00062c
Popis:	An efficient synthetic approach for the spiro-linked [7-5-6-5] all-carbon tetracyclic core derivatives of logeracemin A, a unique dimeric calyciphylline A-type alkaloid, from the known methyl cyclohept-1-ene carboxylate was described. The synthesis features a bioinspired successive Michael/double aldol/dehydration reaction sequence, which might indicate the possibility of a more efficient alternative biosynthetic pathway of logeracemin A.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::93bde1250cc4dc13c97ccae4d15c8abc https://doi.org/10.1039/c9qo00062c Zobrazit plný text záznamu