Synthesis and Biological Evaluation of Carbocyclic Nucleosides with 2′,3′-Dihomo-xylo-carbocyclic or Carbocyclic Fused to a Tetrahydrofuran Ring

Autor:	María José Figueira, Franco Fernández, Erik De Clercq, Olga Caamaño, Jan Balzarini, J. Enrique Rodríguez-Borges
Rok vydání:	2004
Předmět:	Antitumor activity Purine chemistry.chemical_compound chemistry Pyrimidine Stereochemistry Organic Chemistry Ring (chemistry) Catalysis Derivative (chemistry) Tetrahydrofuran Octane Biological evaluation
Zdroj:	Synthesis. 2004:1991-1995
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-2004-829141
Popis:	New purinyl 2',3'-dihomo-xylo-carbocyclic pentafuranosides and carbocyclic nucleosides fused with tetrahydrofuran ring were synthesized from (′)-c-4-amino-r-1,c-2,t-3-cyclopentanetrimethanol (8). The strongly acid medium in which the purine system was completed on pyrimidine derivative 9 caused condensation of the cis-hydroxymethyl groups, giving rise to a 3-oxabicyclo[3.3.0]octane structure. None of the new compounds exhibited more than very modest antiviral or antitumor activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::93b5d6f9d838515e0a32fc5c654abd9d https://doi.org/10.1055/s-2004-829141 Zobrazit plný text záznamu