Effect of Dendrobium loddigesii Rolfe Methanol Extract on Melanogenesis in α-MSH Stimulated B16F10 Cells
| Autor: | Byoung Man Kang, Jung Hee Cho, Won Seok Jung, Chul Gu Bean, Ji-Hun Jang, Ki Ho Lee, Ho Kyung Jung, Jun Hwan Yeo, Seong Cheol Kim, Mi Ok Sim |
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| Rok vydání: | 2015 |
| Předmět: |
biology
Traditional medicine business.industry Tyrosinase Untreated group Pharmaceutical Science Plant Science biology.organism_classification Microphthalmia-associated transcription factor Biochemistry Genetics and Molecular Biology (miscellaneous) Melanin Dendrobium loddigesii Medicine Tyrosinase activity business Agronomy and Crop Science |
| Zdroj: | Korean Journal of Medicinal Crop Science. 23:298-304 |
| ISSN: | 2288-0186 1225-9306 |
| DOI: | 10.7783/kjmcs.2015.23.4.298 |
| Popis: | *Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun 529-851, Korea.**Research Institute, Gyeongsangnamdo Agricultural Research and Extension Services, Changwon 641-920, Korea.***Namhae Sub-Station, National Institute of Horticultural and Herbal Science, RDA, Namhae 668-812, Korea.ABSTRACT : Dendrobium loddigesii (DL) is a valuable and versatile herbal medicine with the anecdotal claims of anti-oxi-dant and anti-inflammation. In the present study, we investigated the whitening effects of DL under various conditions withB16F10 melanoma cells. The DL extract inhibited melanin contents and tyrosinase activity in a dose-dependent manner,compared with untreated group. Treatment of the DL extract effectively suppressed the α-MSH-stimulated melanin forma-tion, tyrosinase activity and dendrite outgrowth. Moreover, the α-MSH-induced mRNA expressions of tyrosinase-relatedprotein-1 (TRP-1), tyrosinase-related protein-2 (TRP-2), microphthalmia-associated transcription factor (MITF) and pro-tein expression of tyrosinase were significantly attenuated by DL treatment. These results indicate that DL may be a greatcosmeceutical ingredient for its whitening effects.Key Words : Dendrobium loddigesii, Whitening, Melanin, Tyrosinase |
| Databáze: | OpenAIRE |
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