Significance of Plasma Apoptosis Inhibitor of Macrophage Concentrations in Patients with Obstructive Sleep Apnea Syndrome: A New Biological Indicator of Severity and Treatment Responses
| Autor: | Shigeru Sakurai, Tsuguo Nishijima, Fumitaka Mito, Akira Suwabe |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.diagnostic_test Apoptosis Inhibitor business.industry medicine.medical_treatment Monocyte Polysomnography medicine.disease Obesity Gastroenterology nervous system diseases respiratory tract diseases Obstructive sleep apnea medicine.anatomical_structure stomatognathic system Apnea–hypopnea index Internal medicine medicine Macrophage Continuous positive airway pressure business |
| Zdroj: | Journal of Sleep Disorders & Therapy. |
| ISSN: | 2167-0277 |
| DOI: | 10.4172/2167-0277.1000219 |
| Popis: | Background: It has been reported that a 10% increase in s body weight predicts a 6-fold increase in the odds of developing moderate to severe obstructive sleep apnea syndrome (OSAS). Blood levels of apoptosis inhibitor of macrophage (AIM), produced by macrophages, increase with obesity progression. We aimed to investigate the association between plasma AIM levels and OSAS severity. We hypothesized that plasma AIM levels are influenced by OSAS severity. Methods: Plasma levels of AIM, monocyte chemotactic protein-1 (MCP-1), and ln high sensitivity-C-reactive protein were measured by ELISA in 97 male participants. Blood samples were obtained after overnight polysomnography (PSG) before and after nasal continuous positive airway pressure (nCPAP) treatment. Results: In 97 OSAS patients, their plasma AIM levels were positively correlated with the apnea hypopnea index (AHI) (r=0.353, p=0.0003) and oxygen desaturation of >3% events per hour (r=0.302, p=0.0025). Plasma AIM levels were significantly higher in patients with moderate to severe OSAS (AHI 15; 1,144.3 ± 342.5 ng/mL, mean + SD) than in mild OSAS (5 AHI 20, plasma AIM levels significantly decreased following nCPAP treatment (p |
| Databáze: | OpenAIRE |
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