A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population
| Autor: | M. Niven, Karl A. Metcalfe, P. A. Biro, E Tuomilehto-Wolf, J. Tuomilehto, M. J. Fennessy, Graham A. Hitman |
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| Rok vydání: | 1994 |
| Předmět: |
Genetics
endocrine system education.field_of_study endocrine system diseases Endocrinology Diabetes and Metabolism Population Haplotype nutritional and metabolic diseases Human leukocyte antigen Biology medicine.disease HLA-A immune system diseases Diabetes mellitus HLA-DQ Internal Medicine HLA-DR medicine Allele education |
| Zdroj: | Diabetologia. 37:937-944 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/bf00400951 |
| Popis: | In Finland the haplotype A2, Cw1, B56, DR4, DQ8 is the third most common haplotype in insulin-dependent diabetic (IDDM) patients and has the highest haplotype-specific absolute risk for IDDM. Cw1, B56, DR4, DQ8 haplotypes containing HLA-A alleles other than A2 are infrequent in the population and are not associated with IDDM. Comparison of the A2 and non-A2 haplotypes at the DNA level showed that they were identical at HLA-B,-DR, and -DQ loci. Evidence that class I alleles confer susceptibility to IDDM was obtained from the two HLA-C, -B, -DR and -DQ haplotypes most frequently found in IDDM patients in Finland. A24, A3 and A2 on the Cw3, B62, DR4, DQ8 haplotype, and A28, A2 and A1 on the Cw7, B8, DR3, DQ2 were all found to be associated with IDDM. In Finland these seven haplotypes, including A2, Cw1, B56, DR4, DQ8, account for 33% of diabetic haplotypes and 10.3% of non-diabetic haplotypes (p |
| Databáze: | OpenAIRE |
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