Rupture of chordae tendineae in patients with β-thalassemia
| Autor: | Dimitrios Farmakis, Athanasios Aessopos, Spyros Deftereos, Evangelos Polymeropoulos, Anastasios Giakoumis |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Heart disease business.industry Thalassemia Population Hematology General Medicine medicine.disease Pseudoxanthoma elasticum Pulmonary hypertension Surgery medicine.anatomical_structure Internal medicine cardiovascular system medicine Cardiology Mitral valve prolapse cardiovascular diseases Chordae tendineae business education Calcification |
| Zdroj: | European Journal of Haematology. 72:296-298 |
| ISSN: | 0902-4441 |
| DOI: | 10.1111/j.1600-0609.2004.00213.x |
| Popis: | Cardiac disease is the primary cause of mortality in beta-thalassemia patients. Except for ventricular dysfunction and pulmonary hypertension that represent the main forms of heart disease in these patients, valvular abnormalities including valvular regurgitation, endocardial thickening and calcification and mitral valve prolapse have also been described. Here we present two patients with thalassemia major and mitral chordal rupture, a previously undescribed abnormality in this population. Pathogenesis of this finding may involve thalassemia-related pseudoxanthoma elasticum-like syndrome, a diffuse elastic tissue defect, which is observed with a notable frequency in these patients and has been associated with numerous cardiovascular complications, including valvular ones. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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