Synthesis, complexing ability, and antidote activity of N′-allyloxyethyldiethyl-enetriamine-N,N, N″, N″-tetraacetic acid

Autor: V. G. Yashunskii, N. M. Okolelova, E. R. Lyubchanskii, L. I. Tikhonova, O. I. Samoilova
Rok vydání: 1984
Předmět:
Zdroj: Pharmaceutical Chemistry Journal. 18:101-105
ISSN: 1573-9031
0091-150X
DOI: 10.1007/bf00758836
Popis: The occurrence of one point of inflection at a ~ 2 on the potentiometric titration curve of the acid (III) (Fig. i) shows that the first buffer region corresponds to the deprotonation of the carboxyl groups, and the second to dissociation of the protons on the nitrogen atoms (a is the number of moles of alkali added per mole of acid). The data in Table i, showing the calculated values for the dissociation constants of (III) [together with, for comparison, the analogous constants for acids (I) and (II)], show that the complexone has a betaine structure, similar to (II). However, the presence of an allyloxyethyl group in place of a carboxymethyl group has a considerable effect on deprotonation. The removal of the first two protons from the acid (!II) is hindered, and consequently the KI and K2 values for this compound are much
Databáze: OpenAIRE
Externí odkaz: