Modeling study on calcium-activated dynamics of neuronal dendrites
| Autor: | Mitsuaki Yamamoto, Norihiro Katayama, Yoshinari Mizutani, Mitsuyuki Nakao |
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| Rok vydání: | 2003 |
| Předmět: |
Physics
Quantitative Biology::Neurons and Cognition chemistry.chemical_element Dendrite Neurophysiology Calcium Plateau (mathematics) Quantitative Biology::Subcellular Processes medicine.anatomical_structure chemistry Excitatory postsynaptic potential medicine Oscillation (cell signaling) Neuron Biological system Bifurcation |
| Zdroj: | [Proceedings 1992] IJCNN International Joint Conference on Neural Networks. |
| DOI: | 10.1109/ijcnn.1992.227121 |
| Popis: | A mathematical model of active neuronal dendrites is constructed in the discrete form based on physiological information. The dynamics of this model are described by calcium-activated regenerative processes with threshold and a calcium accumulation system which changes the dynamical properties of the model. The model is capable of reproducing a stable oscillation in response to a maintained current simulation. The model can also reproduce a calcium-activated plateau potential based on a bifurcation mechanism parameterized by an intracellular calcium concentration. These dynamical properties coincide with that of an actual neuron. Simulations were performed related to an interaction among propagating excitatory potentials on a dendrite model where single compartments were longitudinally connected. Based on the simulation results, possible functions of the dynamical properties of the model are discussed. > |
| Databáze: | OpenAIRE |
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