Oral Vitamin B12 Supplementation After Roux-en-Y Gastric Bypass: a Systematic Review
Autor: | Peter K. Small, Kamal Mahawar, Chetan Parmar, Alastair Reid, Rishi Singhal, William R. J. Carr, Neil Jennings, Lindes Callejas-Diaz, Yitka Graham |
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Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
Nutrition and Dietetics Dose Adult patients business.industry Endocrinology Diabetes and Metabolism Gastric bypass nutritional and metabolic diseases 030209 endocrinology & metabolism English language Roux-en-Y anastomosis Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Oral route Oral vitamin Medicine 030211 gastroenterology & hepatology Surgery Vitamin B12 business |
Zdroj: | Obesity Surgery. 28:1916-1923 |
ISSN: | 1708-0428 0960-8923 |
Popis: | Many respectable guidelines recommend lifelong vitamin B12 injections for Roux-en-Y gastric bypass (RYGB) patients in the absence of lack of consensus on the efficacy of oral route of prophylaxis and the appropriate doses needed for this purpose. The purpose of this review was to examine the published English language scientific literature in accordance with PRISMA principles to find out if orally given vitamin B12 is adequate for prophylactic purposes in RYGB patients and the appropriate dosages needed for this purpose if it is. We examined the PubMed database for all English language articles examining various doses of oral vitamin B12 supplementation after proximal RYGB in adult patients. The search revealed 19 such articles. The data suggest that oral vitamin B12 supplementation doses of ≤ 15 μg daily are insufficient to prevent deficiency in RYGB patients. Higher supplementation doses show better results and it appears that a dose of 600.0 μg vitamin B12 daily is superior to 350.0 μg daily suggesting an incremental dose-response curve. It further appears that supplementation doses of 1000.0 μg vitamin B12 daily lead to an increase in B12 levels and are sufficient for the prevention of its deficiency in most RYGB patients. The review finds that oral supplementation doses of ≤ 15 μg vitamin B12 daily are inadequate for prophylaxis of vitamin B12 deficiency in adult RYGB patients but doses of 1000 μg vitamin B12 daily might be adequate. Future studies need to examine this and even higher oral doses for vitamin B12 supplementation for patients undergoing RYGB. |
Databáze: | OpenAIRE |
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