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Both manual and automated systems for collecting source plasma are available now, with manual methodology being progressively phased out. Automated methods rely on one of three technologies — centrifugation, membrane filtration, and centrifugation combined with membrane filtration. Each of these has been in use for at least several years and all have proven acceptable with respect to the primary issues of donor safety and plasma quality [1–11]. In selecting a specific system a number of criteria should be considered. They include: donor safety;the blood products required (plasma alone, or plasma plus platelets);cost of instrumentation and associated disposables; frequency of “down time”; and availability of service from the manufacturer (or adequate repair training of center staff). Also of importance are life cycle costing; regulatory status; and the degree of user friendliness and its impact on the number of procedures one individual can comfortably supervise. The intent of this review is to discuss the me hodologies and, in a general way, compare the systems. In addition, some approaches to plasma collection will be described. |
