Sodium Diphenyl Hydantoinate in the Treatment of Convulsive Disorders

Autor:	H. Houston Merritt, Tracy J. Putnam
Rok vydání:	1984
Předmět:	Medical treatment business.industry medicine.drug_class medicine.medical_treatment General Medicine Quantitative determination Convulsive Seizures Sedative Anesthesia Medicine Surgical excision business Convulsive disorders Anticonvulsant drugs Ketogenic diet
Zdroj:	JAMA: The Journal of the American Medical Association. 251:1062-1067
ISSN:	1538-3598 0098-7484
Popis:	Good results in the treatment of patients with convulsive seizures have been obtained by a variety of methods, such as medical treatment with bromides or barbituric acid compounds, the ketogenic diet, restriction of fluids, and the surgical excision of scars or irritable cortical foci. In spite of these various therapeutic means there are a great number of patients who are not relieved of their attacks or are helped only temporarily by treatment. The fact that treatment by anticonvulsant drugs is at present the most widely used and on the whole the most effective method of therapy suggested to us the possibility that a direct and systematic experimental search might reveal more potent and less sedative compounds. With this idea in mind we devised an experimental procedure 1 which would produce convulsive seizures in animals at a constant threshold andwhich would allow for a qualitative and roughly quantitative determination of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::93746e1fa99ce838d84ac5b6a4c4c5dd https://doi.org/10.1001/jama.1984.03340320048027 Zobrazit plný text záznamu