Pseudolaric Acid B Inhibits Proliferation, Invasion, and Angiogenesis in Esophageal Squamous Cell Carcinoma Through Regulating CD147
| Autor: | Zhe Yin, Zhi-Qiang Wang, Hua-Rong Cai, Yue-Quan Jiang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pharmacology MMP2 Chemistry Angiogenesis Pharmaceutical Science Esophageal cancer medicine.disease digestive system diseases In vitro 03 medical and health sciences 030104 developmental biology 0302 clinical medicine In vivo Apoptosis Cell culture 030220 oncology & carcinogenesis Drug Discovery Cancer cell Cancer research medicine neoplasms |
| Zdroj: | Drug Design, Development and Therapy. 14:4561-4573 |
| ISSN: | 1177-8881 |
| DOI: | 10.2147/dddt.s269915 |
| Popis: | Background Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor of the digestive system. Studies have shown that pseudolaric acid B (PAB) has several pharmacological effects like anti-microtubule, anti-angiogenesis, and antitumor functions, while the effect and mechanism of PAB on esophageal cancer are still unclear. This study was designed to investigate the effects of PAB on ESCC. Methods To study the effects of PAB on the biological function through a series of in vitro and in vivo experiments. Results The results revealed that PAB inhibited the proliferation, invasion, and migration, but promoted the apoptosis of ESCC. Moreover, PAB restrained the growth of cancer cells in vivo and inhibited the angiogenesis of HUVEC in mice with ESCC. CD147 expression was increased in the esophageal squamous cell lines, and interference with CD147 hindered the proliferation, invasion, and migration of ESCC cells, and inhibited the growth and angiogenesis of the esophageal squamous cell line. PAB reduced the expression of CD147 in vivo and in vitro. The expression of MMP2, 3, and 9 was increased after overexpression of CD147, which provided the opportunity to reverse the role of PAB in inhibiting proliferation, invasion, migration, and angiogenesis of ESCC. Discussion The results revealed that PAB inhibited the proliferation, invasion, migration, and angiogenesis of ESCC in vitro and in vivo by CD147. PAB is a promising monomer for therapy of ESCC, providing references for future research on ESCC treatment. |
| Databáze: | OpenAIRE |
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