Synthesis of Metabolites and Related Substances of Rabeprazole, an Anti-Ulcerative Drug

Autor:	Boluggodu Vijaya Bhaskar, Padi Pratap Reddy, Ganta Madhusudhan Reddy, Kaga Mukkanti
Rok vydání:	2008
Předmět:	Drug chemistry.chemical_classification Chromatography Sulfide media_common.quotation_subject Organic Chemistry Inorganic chemistry Rabeprazole Bulk drug Proton pump Sulfone chemistry.chemical_compound chemistry medicine Rabeprazole Sodium medicine.drug media_common
Zdroj:	Synthetic Communications. 39:278-290
ISSN:	1532-2432 0039-7911
Popis:	Rabeprazole sodium (Aciphex®) is a gastric proton pump inhibitor used for the prevention and treatment of gastric acid–related diseases. During the synthesis of bulk drug of rabeprazole sodium, we have observed metabolites rabeprazole sulfide and rabeprazole sulfone and related substances rabeprazole-N-oxide, rabeprazole sulfone-N-oxide, N-aralkyl rabeprazole, chloro rabeprazole, and methoxy rabeprazole as impurities in the drug substance. The present work describes the synthesis and characterization of these compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::936110b12f110ebcb92169d95a5960f7 https://doi.org/10.1080/00397910802372541 Zobrazit plný text záznamu