An Improved Modeling of Parkinson’s Tremor and Investigation of Some Approaches to Remove this Symptom

Autor:	M. Pooyan, F. Ghoreishian
Rok vydání:	2021
Předmět:	Deep brain stimulation Supplementary motor area business.industry medicine.medical_treatment Central nervous system Thalamus General Engineering medicine.anatomical_structure Dopamine Peripheral nervous system Cortex (anatomy) Basal ganglia medicine business Neuroscience medicine.drug
Zdroj:	International Journal of Engineering. 34
ISSN:	1735-9244 1728-144X
DOI:	10.5829/ije.2021.34.05b.20
Popis:	In this research, an improved model of Parkinsonian tremor is presented by using a mathematical and computational approach. In Parkinson’s disease (PD), an abnormal signal is produced by basal ganglia (BG). This signal goes to the thalamus, then enters cortex and after interaction with peripheral system goes to muscle and finally appears as tremor. In the presented model, all of the mentioned process are simulated. Also, the skeletal muscle model as well as the central nervous system (basal ganglia, thalamus, cortex and supplementary motor area) and peripheral nervous system (spinal reflex) mechanisms are considered. In addition, two methods for tremor suppression are applied in this paper, 1) deep brain stimulation (DBS) which affects dopamine level in BG and 2) a mechanical method which is based on a negative feedback. The accuracy and efficiency of the presented simulation are demonstrated by comparison of the obtained results with those obtained by clinical tests.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::935bea095a53d1ab4969704210a78695 https://doi.org/10.5829/ije.2021.34.05b.20 Zobrazit plný text záznamu