| Autor: |
Henry Riyanto Sofyan, Rahmad Mulyadi, Tiara Bunga Mayang Permata, Sudibio Sudibio, Soehartati Gondhowiardjo, Handoko Handoko, Henry Kodrat, Renindra Ananda Aman, Jellyca Anton, Endang Nuryadi |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Open Access Macedonian Journal of Medical Sciences. 9:1410-1416 |
| ISSN: |
1857-9655 |
| DOI: |
10.3889/oamjms.2021.7502 |
| Popis: |
Aims: This study was done to assess the survival of patients with glioblastoma multiform and to identify factors that can affect patient survival. Materials and methods: From January 2015 to December 2019, 55 patients with histopathologically confirmed glioblastoma multiform and received adjuvant radiation/chemoradiation in our department were retrospectively analyzed. Results: The median overall survival (OS) for entire cohort was 13 months and 1-year OS and 2-year OS rate were 52.7% and 3.6% with the mean follow-up period was 12 months. In univariate analysis, age (≤50 years vs >50 years, p=0.02), performance status (≥90 vs 70-80 vs 20.4cm3, p=0.001) and time to initiate adjuvant therapy (6 weeks, p=0.01) were significantly affect overall survival. In multivariate analysis, RTOG RPA classification and involvement of parietal lobes were independent prognostic factors for overall survival. Conclusions: RTOG RPA classification that consisted of age and performance status is an independent prognostic factor for the clinical outcome of GBM. Besides this well-known factor, we also identified the involvement of parietal lobe gives a strong negative influence on survival of GBM patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
