New Mixed Li/Mg and Li/Mg/Zn Amides for the Chemoselective Metallation of Arenes and Heteroarenes

Autor:	Paul Knochel, Stefan H. Wunderlich, Giuliano C. Clososki, Christoph J. Rohbogner
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Chemistry medicine.drug_class Metalation Organic Chemistry chemistry.chemical_element Carboxamide Homogeneous catalysis Zinc Medicinal chemistry Chemical synthesis Heterocyclic compound medicine Physical and Theoretical Chemistry Chemoselectivity Solubility
Zdroj:	European Journal of Organic Chemistry. 2009:1781-1795
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.200801277
Popis:	New mixed Li/Mg and Li/Mg/Zn amides have been synthesized starting from readily prepared secondary amines. They allow a highly chemoselective directed magnesiation or zincation of various polyfunctional aromatics and heteroaromatics. The kinetic basicity, solubility and stability of these new bases have been compared with those of the corresponding 2,2,6,6-tetramethylpiperamide-derived bases.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Databáze:	OpenAIRE
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