Effect of Neonatal Diethylstilbestrol Exposure on Volume of the Sexually Dimorphic Nucleus of the Preoptic Area of the Hypothalamus and Pituitary Responsiveness to Gonadotropin-Releasing Hormone in Female Rats of Known Anogenital Distance at Birth1
| Autor: | Sherry Dixon, Claude L. Hughes, Kenneth A. Faber, L Ayyash |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
endocrine system
medicine.medical_specialty urogenital system Anogenital distance Diethylstilbestrol Cell Biology General Medicine Gonadotropin-releasing hormone Biology Castrated Female Preoptic area Endocrinology Reproductive Medicine Hypothalamus Internal medicine medicine Sexually dimorphic nucleus Corn oil medicine.drug |
| Zdroj: | Biology of Reproduction. 48:947-951 |
| ISSN: | 1529-7268 0006-3363 |
| DOI: | 10.1095/biolreprod48.5.947 |
| Popis: | The effects of neonatal diethylstilbestrol (DES) exposure on the volume of the sexually dimorphic nucleus of the preoptic area of the hypothalamus (SDN-POA) and on GnRH-stimulated LH secretion were investigated in castrated female rats of known anogenital distance (AGD) at birth. The AGD was measured in females on the day of birth, and 0.1 μg DES or corn oil was injected from Days 1 through 10 of life. The volume of the SDN-POA was significantly larger in animals that had received DES than in those that had received corn oil. The largest SDN-POA volumes were seen in DES-treated animals that had long (>1.4 mm) AGDs, and the smallest volumes in corn oil-treated females that had short (≤1.4 mm) AGDs |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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