| Autor: |
Matteo Fecchio, Camilla Derchi, Renzo Comolatti, Mario Rosanova, Adenauer G. Casali, Sasha D'Ambrosio, Marcello Massimini, Alessandro Viganò, Silvia Casarotto, Alice Mazza, Sara Parmigiani, Simone Sarasso, A. Comanducci |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Clinical Neurophysiology. 130:e110 |
| ISSN: |
1388-2457 |
| DOI: |
10.1016/j.clinph.2019.04.588 |
| Popis: |
Introduction Peripheral as well as direct cortical stimulations have been classically used to probe the reactivity of thalamocortical circuits across brain states, showing consistent state-dependent modifications. Methods Here we aim at directly comparing state-dependent changes across the wake/sleep cycle of the electroencephalographic (EEG) responses to transcranial magnetic stimulation (TMS – applied over premotor and parietal areas) and to electrical median nerve stimulation (EMNS - applied at an intensity able to reproducibly elicit thumb movements) in two groups of 8 healthy individuals each. Results By tuning stimulation parameters, we roughly equalized the strength of brain activation elicited by TMS and EMNS during wakefulness and achieved a similar (p = 0.8) overall (0–600 ms) global mean field power (GMFP). The time-course of wakefulness GMFP significantly peaked (p Conclusions Despite a common reduction of complexity during sleep, brain activation elicited by the two stimulation approaches reveals different state-dependent changes, highlighting the presence of cortical bistability in the case of TMS and of subcortical gating in the case of EMNS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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