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Objective: Algan hemostatic agent (AHA) is a plant-basedhemostatic agent produced in Turkey. Although, there is a greatimprovement in the hemostatic technologies, more effectivehemostatic products are required to be produced. The aim ofthis study was to demonstrate the efficacy of AHA in a partialsplenectomy model in rats. In addition, in this model, postoperativeabdominal adhesion was evaluated.Materials and Methods: In this study 5-7 weeks old 64rats were used. Rats were randomly divided into 8 groups, eachconsisting of eight rats (4 groups heparinized and 4 groups nonheparinized).Experimental splenectomy was performed and thegauze impregnated with saline was applied to the control group forthe hemorrhage control, the gauze impregnated with liquid AHA,gel and powder form of AHA, was applied to the experimentalgroups.Results: The time to reach complete homeostasis wassignificantly shorter in all AHA groups compared to the controlgroup. The powder and the gel forms of AHA stopped the bleedingin heparinized and non-heparinized groups in 1 second. The AHAfluid (sponge) form stopped the bleeding in the first applicationin the control group less than 10 seconds and the second timeapplication was not necessary. The bleeding was able to becontrolled in the heparinized control group (saline impregnatedsponge) by 55 seconds and in the non-heparinized control groupby 38 seconds.Conclusion: This study showed that AHA is a highly effectivehemostatic agent, which would be beneficial in controllinghemorrhage. |
