Preliminary Results of a Double Perfusion Schedule with Melphalan in Measurable Melanoma

Autor:	Joost M. Klaase, B. B. R. Kroon, C. Benckhuijsen, H. R. Franklin, A. N. van Geel
Rok vydání:	1990
Předmět:	Oncology Drug Melphalan medicine.medical_specialty Chemotherapy Isolation perfusion business.industry medicine.medical_treatment media_common.quotation_subject Melanoma Therapeutic effect medicine.disease Internal medicine Toxicity medicine business Perfusion media_common medicine.drug
Zdroj:	Progress in Regional Cancer Therapy ISBN: 9783642748202
DOI:	10.1007/978-3-642-74818-9_32
Popis:	Regional isolation perfusion of the limbs is now becoming a standard procedure worldwide. Its advantage is that a high dose of cytostatic drug can be administered to an isolated tumor-bearing region, localizing and enhancing the therapeutic effect without producing the generalized toxicity typical of systemic chemotherapy. The disadvantages of such intrasurgical chemotherapy are that the duration and frequency of drug administration are limited for technical reasons. In other words, the theory of “fractionation and protraction” [7], increasing the difference in tolerance between malignant and normal cells, is difficult to realize.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::932c3df30e46381057a6173bd7c8245f https://doi.org/10.1007/978-3-642-74818-9_32 Zobrazit plný text záznamu