Characterization of pulmonary lesions in patients with suspected lung cancer: computed tomography versus [18F]fluorodeoxyglucose-positron emission tomography/ computed tomography

Autor: Peter Meldgaard, Hans Henrik Torp Madsen, Torben Riis Rasmussen, Henrik Hager, Hans K. Pilegaard, Karin Hjorthaug, Michael Rehling, Stefan Walbom Harders, Finn Rasmussen, Johanne Bach Andersen, Anne Kirstine Arveschoug
Rok vydání: 2012
Předmět:
Zdroj: Cancer Imaging. 12:437-446
ISSN: 1470-7330
DOI: 10.1102/1470-7330.2012.0035
Popis: Pulmonary nodules are of high clinical importance, given they may prove to be an early manifestation of lung cancer. Pulmonary nodules are small, focal, radiographic opacities that may be solitary or multiple. A solitary pulmonary nodule is a single, small (≤30 mm in diameter) opacity. Larger opacities are called masses and are often malignant. As imaging techniques improve and more nodules are detected, the optimal management of pulmonary nodules remains unclear. However, the question of malignancy of any given nodule remains the same. A standard contrast-enhanced computed tomography (CT) scan is often the first examination, followed by a number of other examinations. The purpose of this study was to examine the clinical feasibility of CT versus integrated [18F]fluorodeoxyglucose-positron emission tomography (PET)/low-dose CT scan in patients with suspected lung cancer and pulmonary lesions on CT. All results were controlled for reproducibility. We found that when used early in the work-up of the lesions, CT raised the prevalence of lung cancer in the population to the point where further diagnostic imaging examination could be considered futile. We also found that the overall diagnostic accuracy, as well as the classification probabilities and predictive values of the two modalities were not significantly different; the reproducibility of these results was substantial.
Databáze: OpenAIRE
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