Pre-treatment CD8+ tumour-infiltrating lymphocyte density predicts distant metastasis after definitive treatment in patients with stage III/IV hypopharyngeal squamous cell carcinoma

Autor:	A. Kawahara, Koichi Azuma, Takeharu Ono, Hirohito Umeno, Jun Akiba, S Chitose, Tatsuyuki Kakuma
Rok vydání:	2018
Předmět:	0301 basic medicine Oncology medicine.medical_specialty Multivariate analysis business.industry Lymphocyte Retrospective cohort study Hypopharyngeal Carcinoma 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Internal medicine medicine Immunohistochemistry Stage (cooking) Neutrophil to lymphocyte ratio business CD8
Zdroj:	Clinical Otolaryngology. 43:1312-1320
ISSN:	1749-4478
DOI:	10.1111/coa.13171
Popis:	Objectives Although inflammatory markers, such as the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and local immune markers have been shown to have prognostic utility, limited information is available regarding inflammatory and pre-existing tumour-infiltrating lymphocyte density and their association with prognosis in patients with hypopharyngeal squamous cell carcinoma. We investigated the prognostic ability of inflammatory markers and tumour-infiltrating lymphocyte density in stage III and stage IV hypopharyngeal squamous cell carcinoma patients receiving definitive treatment. Design Retrospective cohort study. Setting Kurume University Hospital. Participants Ninety-six stage III or stage IV hypopharyngeal squamous cell carcinoma patients treated at the Kurume University Hospital between 2000 and 2014. Main outcome measures Inflammatory markers and pre-treatment tumour-infiltrating lymphocyte density were examined from recorded haematologic data and immunohistochemical analysis. Results Multivariate analyses showed that the CD8+ tumour-infiltrating lymphocyte density was an independent predictive factor for distant metastasis and overall survival, whereas inflammatory markers, including the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio, were not correlated with distant metastasis or overall survival. Conclusions Higher pre-treatment CD8+ tumour-infiltrating lymphocyte density is a useful predictive biomarker for reduced distant metastasis and better prognosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::931d600996ebff29eb6eb67010fdda8f https://doi.org/10.1111/coa.13171 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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