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Kinetics of coagulation of hemoglobin, in particular, of bovine oxyhemoglobin, in the presence of a Ni(II) salt was measured for the first time. The initial coagulation rate is several times lower than the initial rates of hemoglobin coagulation in the presence of Hg(II), Cd(II), and Zn(II) salts. In hemoglobin at neutral pHs, there is a center of preferential binding with nickel ions (presumably, reactive thiol groups of cysteine), but increasing temperature and pH disturb the selectivity of binding with this center. Hydroxide anions essentially slow down the coagulation rate, which is attributable to their competition for nickel cations. |
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