Sex-Specific Response to Cardiac Resynchronization Therapy
| Autor: | Niraj Varma, Jason M. Lappe, J He, Mark Niebauer, Mahesh Manne, Patrick J. Tchou |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Ejection fraction Left bundle branch block business.industry medicine.medical_treatment Left ventricular size Cardiac resynchronization therapy 030204 cardiovascular system & hematology medicine.disease Sex specific New york heart association 03 medical and health sciences QRS complex 0302 clinical medicine Internal medicine Heart failure cardiovascular system medicine Cardiology cardiovascular diseases 030212 general & internal medicine business circulatory and respiratory physiology |
| Zdroj: | JACC: Clinical Electrophysiology. 3:844-853 |
| ISSN: | 2405-500X |
| Popis: | Objectives In this study, the authors sought to assess the impact of body and heart size on sex-specific cardiac resynchronization therapy (CRT) response rate, according to QRS duration (QRSd) as a continuum. Background Effects of CRT differ between sexes for any given QRSd. Methods New York Heart Association functional class III/IV patients with nonischemic cardiomyopathy and “true” left bundle branch block (LBBB) were evaluated. Left ventricular mass (LVM) and end-diastolic volume were measured echocardiographically. Positive response was defined by left ventricular ejection fraction (LVEF) improvement post-CRT. Results Among 130 patients (LVEF 19 ± 7.1%; QRSd 165 ± 20 ms; 55% female), CRT improved LVEF to 32 ± 14% (p Conclusions Sex differences in the QRSd–response relationship among CRT patients with LBBB were unexplained by application of strict LBBB criteria or by BSA, but resolved by QRSd normalization for heart size using LV mass or volume. |
| Databáze: | OpenAIRE |
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