Tumor testicular del síndrome adrenogenital. A propósito de un caso y diagnóstico intraoperatorio
| Autor: | Alejandro Antúnez Infante, Federico Zeller, Jacob Benguigui Benadiva |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty medicine.diagnostic_test Leydig cell business.industry Anatomy medicine.disease Pathology and Forensic Medicine medicine.anatomical_structure Stroma Adrenogenital syndrome Biopsy Medicine Congenital adrenal hyperplasia Radical surgery Stem cell Differential diagnosis business |
| Zdroj: | Revista Española de Patología. 43:102-104 |
| ISSN: | 1699-8855 |
| DOI: | 10.1016/j.patol.2010.01.004 |
| Popis: | We present a case of a 34 years old male with congenital adrenal hyperplasia caused by 21-hidroxilase deficiency, diagnosed during his childhood. Currently he presents multiple testicular hypoechogenic and bilateral masses. We chose to perform intraoperatory biopsy in one of these lesions, observing a microscopic appearance constituted by cords and trabeculae of large polygonal cells with abundant cytoplasm and round nuclei with fine chromatin pattern similar to Leydig cells, including meandering fibrous tracts of more or less thickness, which helped us delivering the diagnosis of testicular tumor of adrenogenital syndrome. In patients with adrenogenital syndrome is typical the arising of bilateral testicular tumors as a result of elevated levels of adrenocorticotropin hormone (ACTH) in peripheral blood. Current theories directed to an origin from pluripotential stem cells from testicular stroma. These tumors are morphologically, biochemically and radiologically very similar to Leydig cell tumours, so it is very important to make a correct differential diagnosis and avoid radical surgery performed classically with these lesions. |
| Databáze: | OpenAIRE |
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