A phthalocyanine–mestranol conjugate for photodynamic therapy prepared via click chemistry

Autor:	Jana Ivincová, Petr Zimcik, Kamil Kopecky, Miroslav Miletin, Veronika Novakova
Rok vydání:	2010
Předmět:	Chemistry medicine.medical_treatment Organic Chemistry Photodynamic therapy Photochemistry Biochemistry Cycloaddition chemistry.chemical_compound Drug Discovery medicine Phthalocyanine Click chemistry Azide Absorption (chemistry) Derivative (chemistry) Conjugate
Zdroj:	Tetrahedron Letters. 51:1016-1018
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2009.12.075
Popis:	Introduction of an azide group onto the periphery of a photodynamically effective phthalocyanine (Pc) derivative gives a useful building block for the preparation of Pc conjugates via Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (‘click chemistry’). In this way, Pc–mestranol and Pc–hept-1-yne conjugates (for comparison purposes) are synthesized and their absorption, photochemical, and photophysical properties are studied. The conjugate retains the advantageous photophysical and photochemical properties of Pc. Conjugation with mestranol may lead to improved localization in tumors whereas the Pc unit is responsible for the photodynamic effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::92fbedb4dc2264290ba9a69900529b00 https://doi.org/10.1016/j.tetlet.2009.12.075 Zobrazit plný text záznamu Full Text from ScienceDirect