AB0049 ASSOCIATION WITH LEPTINEMIA AND Q223R (rs1137101) POLYMORPHISM OF LEPR GENE IN FEMALE PATIENTS WITH KNEE OSTEOARTHRITIS
| Autor: | L. Shvets, V. Novoseletskyi, V. Khomenko, L. Perebetiuk, M. Stanislavchuk |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Annals of the Rheumatic Diseases. 81:1159.2-1159 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2022-eular.2778 |
| Popis: | BackgroundKnee Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide. Poor early diagnostics, growing share of seniors in the population structure, the need for genetic or other molecular biomarkers to improve safety, efficacy, and outcome of treatment of OA patients make up the key issues of scientific interest.ObjectivesTo assess the association between serum leptin concentrations, the LEPR gene Q223R(rs1137101) polymorphism in patients with knee OA.MethodsThe participants in this study (knee OA patients = 99, control group (healthy women) = 62) underwent blood measurement to LEPR Q223R(rs1137101) genotyping assay and leptin serum levels. We analyzed the relationship with multivariate regression models using generalized linear models with binomial link function.ResultsIn this way, allele frequency and genotypic variant specificity for polymorphic variant Q223R(rs1137101) of LEPR gene in women with OA of knee joints were determined. The frequency of the variant allele G(Arg) in the group of patients with OA of the knee joints was 0.54 and in the control group 0.43. The results were unreliable, although the nature of the trend was small (p = 0.06). In patients with OA, the genotype Q223R(rs1137101) of the LEPR gene was significantly subdivided according to the Hardy-Weinberg law (p = 0.002), which was due to the higher frequency of homozygotes of both types, while theoretically scoring with the same status. The association of the Q223R(rs1137101) polymorphism of the LEPR gene with the risk of developing OA of the knee joints in the recessive model of decay (GG/AA + AG) was revealed: odds ratio (OR) = 2.15 (95% CI: 1.03-4.50), p = 0.04. There was no correlation between the Q223R(rs1137101) polymorphism of the LEPR gene and such clinical and laboratory indicators as clinical form, body mass index, and blood serum leptin concentration. Carriers of AG (Gln/Arg) + GG(Arg/Arg) genotypes have a significantly higher risk of developing rapid X-ray progression of OA (II and III X-ray stages, due to I) after 5 years of diseases: OR = 5.17 (95% CI: 1.04 - 25.57), р = 0.03.ConclusionOur results suggest that the patients with knee OA the AG (Gln/Arg) and GG (Arg/Arg) genotype carriers have statistically significant higher risk of OA.Further study of this issue is needed.Disclosure of InterestsNone declared |
| Databáze: | OpenAIRE |
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