Serum 8-hydroxy-2′-deoxyguanosine (8-oxo-dG) levels are elevated in diabetes patients
| Autor: | Jiao Sun, Mats Harms-Ringdahl, Alice Sollazzo, Ellen He, Xudan Lou, Haidong Wang, Sven Skog, Siamak Haghdoost |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
biology business.industry Endocrinology Diabetes and Metabolism Case-control study 8-Hydroxy-2'-deoxyguanosine Elisa assay medicine.disease_cause medicine.disease Gastroenterology Pathogenesis Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine biology.protein Biomarker (medicine) Antibody business Oxidative stress |
| Zdroj: | International Journal of Diabetes in Developing Countries. 35:368-373 |
| ISSN: | 1998-3832 0973-3930 |
| Popis: | The increased oxidative stress in diabetes is known to contribute to the development of diabetes. We investigate whether serum 8-hydro-2′-deoxyguanosine (8-oxo-dG) is associated with diabetes at the time of first diagnosis and evaluate whether it can be used as a reliable biomarker for the oxidative stress in diabetes. The study was designed as a case control study with two groups: patient with diabetes and control. The diabetes group consisted of a total of 28 patients consulting the hospital for the first time and definitely diagnosed for diabetes, and the control group was composed of 65 healthy subjects. Serum 8-oxo-dG was measured by a competitive enzyme-linked immunosorbent assay (ELISA) kit, specially developed to minimize cross-reaction of 8-oxo-dG antibody with serum guanosine. The average serum 8-oxo-dG levels in patients with diabetes and controls were 0.72 ± 0.41 and 0.24 ± 0.14 ng/mL, respectively, statistically significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|