| Popis: |
RESULTS: Histologically, in all proliferative lesions, c-kit and Oct-4 cells were found to reside in nests close to arterioles. These cells radiate outwards from the nest core in early proliferative lesions and further differentiate to cords of CD133 , c-kit and Oct-4 negative cells with stem cell morphology.These cell populations were not seen in the involuting and involuted specimens. In addition, both proliferative and involuting lesions exhibit areas of possible hematopoietic activity as demonstrated by immature erythrocytes and phenotypes of splenic-like cords and blood islands of bone marrow. In vitro, Oct-4 cells, which exhibit phosphatase activity, were isolated. |
