Upfront VIP-reinforced-ABVD (VIP-rABVD) is not superior to CHOP/21 in newly diagnosed peripheral T cell lymphoma. Results of the randomized phase III trial GOELAMS-LTP95
| Autor: | Noel Milpied, Thierry Lamy, Antoine Thyss, Steven Le Gouill, Jean François Rossi, Virginie Lucas, Eric Deconinck, Bernard Desablens, Audrey Simon, Philippe Casassus, Philippe Colombat, Jean Pierre Vilque, Jérôme Jaubert, Frédéric Maloisel, Michel Peoc'h, Charles Foussard, Olivier Tournilhac, Vincent Delwail, Remy Gressin, Houchingue Eghbali |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Oncology
medicine.medical_specialty Chemotherapy Vincristine business.industry medicine.medical_treatment Dacarbazine Hematology CHOP medicine.disease Peripheral T-cell lymphoma Lymphoma Surgery 03 medical and health sciences 0302 clinical medicine ABVD 030220 oncology & carcinogenesis Internal medicine medicine T-cell lymphoma business 030215 immunology medicine.drug |
| Zdroj: | British Journal of Haematology. 151:159-166 |
| ISSN: | 0007-1048 |
| DOI: | 10.1111/j.1365-2141.2010.08329.x |
| Popis: | Peripheral T-Cell lymphomas (PTCL) are relatively rare diseases but appear to be highly aggressive and display worse remission and survival rates than B-cell lymphomas. Despite unsatisfactory results with the cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) regimen, it remains the reference front-line therapy in these diseases, but has not been challenged in phase III trials. The Groupe Ouest Est d'Etude des Leucemies et Autres Maladies du Sang (GOELAMS) devised an alternative therapeutic schedule including etoposide, ifosfamide, cisplatin alternating with doxorubicin, bleomycin, vinblastine, dacarbazine (VIP-reinforced-ABVD; VIP-rABVD) and compared it to CHOP/21 as front-line treatment in non-cutaneous PTCL. All newly diagnosed patients were eligible. The primary objective was to improve the 2-year event-free survival (EFS) rate. Secondary objectives were to compare the response rate, overall survival, and toxicities as well as identify prognostic factors. Eighty-eight patients were identified between 1996 and 2002. Both arms were well balanced for patients' characteristics in terms of histological and clinical presentation. No significant difference was observed between the two arms in terms of 2-year EFS. Anaplastic large cell lymphoma type and Ann Arbor stage I-II were identified as two independent favourable prognostic factors influencing survival. VIP-rABVD was not superior to CHOP/21 in terms of EFS as first-line treatment of PTCL, confirming that CHOP/21 remains the reference regimen in these lymphomas. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text