The use of novel lymphatic endothelial cell-specific immunohistochemical markers to differentiate cutaneous angiosarcomas in dogs
| Autor: | C. H. C. Halsey, Deanna R. Worley, K. M. Curran, J. B. Charles, E. J. Ehrhart |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
CD31 Pathology medicine.medical_specialty General Veterinary 040301 veterinary sciences government.form_of_government 04 agricultural and veterinary sciences Biology medicine.disease 0403 veterinary science Endothelial stem cell 03 medical and health sciences Lymphatic Endothelium 030104 developmental biology Hemangiosarcoma Lymphatic system medicine.anatomical_structure government medicine Vascular Neoplasm Lymphatic vessel Lymphangiosarcoma |
| Zdroj: | Veterinary and Comparative Oncology. 14:236-244 |
| ISSN: | 1476-5810 |
| DOI: | 10.1111/vco.12088 |
| Popis: | Lymphangiosarcomas are uncommon vascular neoplasms that arise from lymphatic endothelial cells (LECs). They efface and replace normal subcutaneous tissue and are characterised by arborising, vascular channels lined by a single layer of pleomorphic endothelial cells and a paucity of erythrocytes. Lymphangiosarcomas are architecturally similar to hemangiosarcomas, a common malignancy of vascular origin arising from blood vascular endothelial cells. Common immunohistochemical markers for vascular endothelium, such as Factor VIII-related antigen (F8RA) and CD31, have traditionally been used to confirm the diagnosis of tumours of vascular origin. However, these markers fail to differentiate between lymphangiosarcoma and hemangiosarcoma, which often show overlapping morphologic features, disparate clinical behaviour and require different treatment modalities. Here we describe the use of two novel LEC-specific markers, lymphatic vessel endothelial receptor-1 (LYVE-1) and prospero-related homeobox gene-1 (PROX-1), to further differentiate between vascular tumours of lymphatic (lymphangiosarcoma) and blood (hemangiosarcoma) endothelial cell origin in the dog. |
| Databáze: | OpenAIRE |
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