Development and initial characterization of 99mTc labeled N-acetyl neuraminic acid for its application in in-vivo imaging of cancer: a preclinical study

Autor:	Devinder K. Dhawan, Ravi Ranjan Kumar, Vijayta Dani Chadha
Rok vydání:	2019
Předmět:	Biodistribution Chromatography Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Pollution High-performance liquid chromatography Thin-layer chromatography Analytical Chemistry Sialic acid chemistry.chemical_compound Nuclear Energy and Engineering chemistry Yield (chemistry) Neuraminic acid Radiology Nuclear Medicine and imaging Selectivity Spectroscopy Preclinical imaging
Zdroj:	Journal of Radioanalytical and Nuclear Chemistry. 322:533-543
ISSN:	1588-2780 0236-5731
DOI:	10.1007/s10967-019-06791-4
Popis:	In the present study, N-acetyl neuraminic acid (Neu5Ac) was labeled with 99mTc and its bioevaluation was performed. Radiolabeling of Neu5Ac was obtained with a maximum labeling yield of 93.6% and was confirmed by instant thin layer chromatography, mass spectra (ESI-MS) and high performance liquid chromatography. The resulting radiocomplex showed hydrophilic properties and stability up to 8 h at room temperature in rat serum and saline. Biodistribution and scintigraphic studies exhibited accumulation of activity in the colon of tumor bearing rats. In conclusion, [99mTc]Tc-N-acetyl neuraminic acid exhibits selectivity for neoplastic colon tissue.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::92bec7fd7ca66a13cb15e018270539d8 https://doi.org/10.1007/s10967-019-06791-4 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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