Viszerale Leishmaniose (Kala-Azar): Eine seltene Differentialdiagnose bei Splenomegalie und Panzytopenie*
| Autor: | M. Baldus, Th. Schleiffer, Horst Brass |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Sodium stibogluconate business.industry Hepatosplenomegaly General Medicine medicine.disease Pancytopenia Gastroenterology Serology Visceral leishmaniasis Methylprednisolone Amikacin Internal medicine parasitic diseases medicine medicine.symptom business medicine.drug Piperacillin |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 114:1876-1881 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-2008-1066842 |
| Popis: | A 53-year-old man developed a septic fever up to 40 degrees C, pancytopenia and hepatosplenomegaly after a holiday in Spain. Administration of piperacillin and amikacin was ineffective, but the fever subsided and partial haematological remission occurred when 1 mg/kg methylprednisolone daily was added. After six months his general condition worsened and pancytopenia with typical inclusion bodies in bone-marrow macrophages was noted, leading to the diagnosis of visceral leishmaniasis (Kala-Azar). The diagnosis was confirmed by serological tests. The causative organism was eliminated and the abnormal findings regressed during treatment with sodium stibogluconate, at first 600 mg/d for two weeks, then 850 mg/d over 16 days, interrupted for 14 days because of side effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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