The development of a non-invasive model to predict the presence of non-alcoholic steatohepatitis in patients with non-alcoholic fatty liver disease
| Autor: | Rocio Lopez, Carol Hawkins, George Boon-Bee Goh, Arthur J. McCullough, Lisa Yerian, Srinivasan Dasarathy, Mangesh R. Pagadala, Naim Alkhouri, Ruth Sargent, Amer Khiyami, Achuthan Sourianarayanane, Jaividhya Dasarathy, Danny Issa, Rish K Pai |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
digestive system Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Hepatology medicine.diagnostic_test biology business.industry Fatty liver Area under the curve nutritional and metabolic diseases medicine.disease digestive system diseases Confidence interval Ferritin 030220 oncology & carcinogenesis Liver biopsy Predictive value of tests biology.protein 030211 gastroenterology & hepatology Steatohepatitis business Body mass index |
| Zdroj: | Journal of Gastroenterology and Hepatology. 31:995-1000 |
| ISSN: | 0815-9319 |
| DOI: | 10.1111/jgh.13235 |
| Popis: | BACKGROUND Non-alcoholic steatohepatitis (NASH) is an advanced and aggressive form of non-alcoholic fatty liver disease (NAFLD), which remains difficult to diagnose without a liver biopsy. Hyperferritinemia has increasingly been associated with the presence of NASH. Hence, we sought to explore the relationship between ferritin and NASH and to develop a composite model based on ferritin to predict the presence of NASH. METHODS A total of 405 patients with biopsy-proven NAFLD were enrolled in the study. Comparison was explored to assess differences between patients with and without NASH, upon which a scoring model was established using variables found to be independent predictors of NASH. RESULTS Among all patients with NAFLD, 291 (72%) had biopsy-proven NASH, and 114 (28%) had non-NASH. Mean age was 48 ± 12 years, and 56% were female. Ferritin was significantly higher in NASH compared with non-NASH patients (184 vs 126, respectively; P |
| Databáze: | OpenAIRE |
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