Controlled epimerization of indolo[2,3-a]quinolizidine derivatives: An efficient total synthesis of (±)-tacamonine
| Autor: | David Din Belle, Arto Tolvanen, Kimmo Karinen, Mauri Lounasmaa |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Quinolizidine
Indole alkaloid 010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Total synthesis Tacamonine 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences 3. Good health chemistry.chemical_compound Yield (chemistry) Drug Discovery Organic chemistry Epimer |
| Zdroj: | Tetrahedron. 54:157-164 |
| ISSN: | 0040-4020 |
| Popis: | Base-catalysed epimerization of the easily accessible trans ester 3 at C-1 gives rise in good yield to the seemingly less stable cis ester 2, which can be converted into the indole alkaloid tacamonine (1) in three steps. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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