Griseofulvin vs. Terbinafine in the Treatment of Tinea Capitis
| Autor: | Mustafa Mohamed Ali Almusallami, Adnan Meteb Mohamed Almezani, Ali Hassan Jaber Alzahrani, Humoud Mansour AlKhalaf, Youssef Mohammad Almodhaibri, Fatimah Mohammed Saeedi, Abdulaziz Mohammed Alsahli, Jumanh Khalid Attiah, Fatema Hassan A. ALAjwad, Somaya Khalid Alsharif, Nawal Hatem Herzallah, Ibrahim Abdullah Al Taha, Maha Fahad Alluqmani |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
biology business.industry Context (language use) Odds ratio medicine.disease Griseofulvin biology.organism_classification Dermatology Treatment efficacy law.invention chemistry.chemical_compound chemistry Randomized controlled trial law medicine Terbinafine Tinea capitis Trichophyton business medicine.drug |
| Zdroj: | The Egyptian Journal of Hospital Medicine. 69:2992-2996 |
| ISSN: | 2090-7125 1687-2002 |
| DOI: | 10.12816/0042845 |
| Popis: | Background: Two oral antifungal agents, griseofulvin and terbinafine, have regulatory approval but it is unknown whether one has superior overall efficacy. Genus-specific differences in efficacy are believed to exist for the two agents. It is not clear at what doses and durations of treatment these differences apply. Purpose: The purposes of this meta-analysis were to determine whether a statistically significant difference in efficacy exists between these agents at a given dose and duration of each in tinea capitis infections overall and to determine whether a genus-specific difference in efficacy exists for these two treatments at a given dose and duration of each. We performed a literature search for clinically and methodologically similar randomized controlled trials comparing 8 weeks of griseofulvin (6.25–12.5 mg⁄kg⁄day) to 4 weeks of terbinafine (3.125–6.25 mg⁄kg⁄day) in the treatment of tinea capitis. A meta-analysis was performed using the Mantel–Haenszel method and random effects model; results were expressed as odds ratios with 95%. Results: Meta-analysis of randomized controlled trials did not show a significant difference in the overall efficacy of the two drugs at the doses specified, but specific efficacy differences were observed based on the infectious species. For tinea capitis caused by Microsporumspp., griseofulvin is superior (p = 0.04), whereas terbinafine is superior for Trichophyton spp. infection (p = 0.04). Conclusion:Our results support species-specific differences in treatment efficacy between griseofulvin and terbinafine and provide a clinical context in which this knowledge may be applied. |
| Databáze: | OpenAIRE |
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