Das stressige Leben des Bacillus subtilis
| Autor: | Regina Kramer, Ingo Hantke, Kürşad Turgay, Heinrich Schäfer |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
biology 030306 microbiology Chemistry Bacillus subtilis Protein aggregation biology.organism_classification medicine.disease_cause Cell biology 03 medical and health sciences In vivo Transcription (biology) medicine Molecular Biology Gene Protein quality Transcription factor Oxidative stress 030304 developmental biology Biotechnology |
| Zdroj: | BIOspektrum. 25:150-152 |
| ISSN: | 1868-6249 0947-0867 |
| Popis: | Here we present Bacillus subtilis as a model system to study protein homeostasis and protein quality control in conjunction with the different layers of its stress response systems. We established a new marker to study protein aggregation in vivo. Furthermore, we observed that the transcription factor Spx, which has already been characterized as a central player to activate transcription of redox-chaperones during heat shock and oxidative stress response, was also able to simultaneously inhibit the transcription of translation-related genes as a second response to stress. |
| Databáze: | OpenAIRE |
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